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Publication Detail
A Registration Approach to Endoscopic Laser Speckle Contrast Imaging for Intrauterine Visualisation of Placental Vessels
  • Publication Type:
    Conference
  • Authors:
    Sato Dos Santos G, Maneas E, Nikitichev D, Barburas A, David AL, Deprest J, Desjardins A, Vercauteren T, Ourselin S
  • Publisher:
    Springer
  • Publication date:
    05/10/2015
  • Published proceedings:
    MICCAI 2015
  • Series:
    Lecture Notes in Computer Science
  • Editors:
    Frangi ,Hornegger ,Navab ,Wells
  • Status:
    Published
  • Name of conference:
    MICCAI 2015, the 18th International Conference on Medical Image Computing and Computer Assisted Intervention
  • Conference place:
    Munich, Germany
  • Conference start date:
    05/10/2015
  • Conference finish date:
    09/10/2015
  • Addresses:
    Translational Imaging Group, CMIC, University College London
    London, NW1 2HE, UK

    Dept. Med. Phys. and Biomed. Eng., University College London
    London, WC1E 6BT, UK

    Institute for Women's Health, University College London
    London, WC1E 6HX, UK

    Dept. of Obstetrics, University Hospitals KU Leuven
    Leuven, Belgium
Abstract
Intrauterine interventions such as twin-to-twin transfusion syndrome procedure require accurate mapping of the fetal placental vasculature to ensure complete photocoagulation of vascular anastomoses. However, surgeons are currently limited to fetoscopy and external ultrasound imaging, which are unable to accurately identify all vessels especially those that are narrow and at the periphery. Laser speckle contrast imaging (LSCI) is an optical method for imaging blood flow that is emerging as an intraoperative tool for neurosurgery. Here we explore the application of LSCI to minimally invasive fetal surgery, with an endoscopic LSCI system based on a 2.7-mm-diameter fetoscope. We establish using an optical phantom that it can image flow in 1-mm-diameter vessels as far as 4 mm below the surface. We demonstrate that a spatiotemporal algorithm produces the clearest images of vessels within 200 ms, and that speckle contrast images can be accurately registered using groupwise registration to correct for significant motion of target or probe. When tested on a perfused term ex vivo human placenta, our endoscopic LSCI system revealed small capillaries not evident in the fetoscopic images.
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Maternal & Fetal Medicine
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Dept of Med Phys & Biomedical Eng
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Dept of Med Phys & Biomedical Eng
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