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Publication Detail
State dependency in Brain Stimulation Studies of Perception and Cognition.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Silvanto J, Muggleton N, Walsh V
  • Publication date:
    2008
  • Pagination:
    447, 454
  • Journal:
    Trends in Cognitive Sciences
  • Volume:
    12
  • Issue:
    12
  • Print ISSN:
    1364-6613
Abstract
We address the importance of understanding initial states of neuronal populations and of state dependent responses in cognitive neuroscience experiments with special emphasis on brain stimulation studies of perception and cognition. The approach we present is based on evidence that behavioral and perceptual effects of TMS are determined by initial neural activation state; by systematically manipulating neural activation states prior to application of TMS, one can selectively target specific, even spatially overlapping neural populations within the affected region. This approach is potentially of great benefit to cognitive neuroscience and remediation programmes as it combines high spatial and functional resolution with the ability to assess causality.
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