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Publication Detail
Evolution of multi-parametric MRI quantitative parameters following transrectal ultrasound-guided biopsy of the prostate
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Latifoltojar A, Dikaios N, Ridout A, Moore C, Illing R, Kirkham A, Taylor S, Halligan S, Atkinson D, Allen C, Emberton M, Punwani S
  • Publisher:
    Nature Publishing Group
  • Publication date:
    21/07/2015
  • Pagination:
    1, 9
  • Journal:
    Prostate Cancer and Prostatic Diseases
  • Status:
    Published
  • Print ISSN:
    1365-7852
  • PII:
    pcan201533
  • Language:
    eng
Abstract
Background:To determine the evolution of prostatic multi-parametric magnetic resonance imaging (mp-MRI) signal following transrectal ultrasound (TRUS)-guided biopsy.Methods:Local ethical permission and informed written consent was obtained from all the participants (n=14, aged 43–69, mean 64 years). Patients with a clinical suspicion of prostate cancer (PSA range 2.2–11.7, mean 6.2) and a negative (PIRAD 1–2/5) pre-biopsy mp-MRI (pre-contrast T1, T2, diffusion-weighted and dynamic-contrast-enhanced MRI) who underwent 10-core TRUS-guided biopsy were recruited for additional mp-MRI examinations performed at 1, 2 and 6 months post biopsy. We quantified mp-MRI peripheral zone (PZ) and transition zone (TZ) normalized T2 signal intensity (nT2-SI); T1 relaxation time (T10); diffusion-weighted MRI, apparent diffusion coefficient (ADC); dynamic contrast-enhanced MRI, maximum enhancement (ME); slope of enhancement (SoE) and area-under-the-contrast-enhancement-curve at 120 s (AUC120). Significant changes in mp-MRI parameters were identified by analysis of variance with Dunnett’s post testing.Results:Diffuse signal changes were observed post-biopsy throughout the PZ. No significant signal change occurred following biopsy within the TZ. Left and right PZ mean nT2-SI (left PZ: 5.73, 5.16, 4.90 and 5.12; right PZ: 5.80, 5.10, 4.84 and 5.05 at pre-biopsy, 1, 2 and 6 months post biopsy, respectively) and mean T10 (left PZ: 1.02, 0.67, 0.78, 0.85; right PZ: 1.29, 0.64, 0.78, 0.87 at pre-biopsy, 1, 2 and 6 months post biopsy, respectively) were reduced significantly (P<0.05) from pre-biopsy values for up to 6 months post biopsy. Significant changes (P<0.05) of PZ-ME and AUC120 were observed at 1 month but resolved by 2 months post biopsy. PZ ADC did not change significantly following biopsy (P=0.23–1.0). There was no significant change of any TZ mp-MRI parameter at any time point following biopsy (P=0.1–1.0).Conclusions:Significant PZ (but not TZ) T2 signal changes persist up to 6 months post biopsy, whereas PZ and TZ ADC is not significantly altered as early as 1 month post biopsy. Caution must be exercised when interpreting T1- and T2-weighted imaging early post biopsy, whereas ADC images are more likely to maintain clinical efficacy.Prostate Cancer and Prostatic Disease advance online publication, 21 July 2015; doi:10.1038/pcan.2015.33.
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