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Publication Detail
An investigation of cortical neuroplasticity following stroke in adults: is there evidence for a critical window for rehabilitation?
  • Publication Type:
    Journal article
  • Authors:
    McDonnell MN, Koblar S, Ward NS, Rothwell JC, Hordacre B, Ridding MC
  • Publication date:
    11/07/2015
  • Journal:
    BMC Neurology
  • Volume:
    15
  • Article number:
    109
  • Status:
    Published
  • Country:
    England
  • Print ISSN:
    1471-2377
  • PII:
    10.1186/s12883-015-0356-7
  • Language:
    English
  • Notes:
    © 2015 McDonnell et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
Abstract
Evidence in animal stroke models suggests that neuroplasticity takes place maximally in a specific time window after an ischaemic lesion, which may coincide with the optimal time to intervene with rehabilitation. The aim of this study is to investigate neurophysiological evidence for a "critical window" of enhanced neuroplasticity in patients following ischaemic stroke, and establish its duration. We will also investigate changes in cortical inhibition following stroke, and the influence this has on functional recovery.
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