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Publication Detail
Maximum-likelihood joint image reconstruction/motion estimation in attenuation-corrected respiratory gated PET/CT using a single attenuation map
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Bousse A, Bertolli O, Atkinson D, Arridge S, Ourselin S, Hutton BF, Thielemans K
  • Publication date:
    01/01/2016
  • Pagination:
    217, 228
  • Journal:
    IEEE Transactions on Medical Imaging
  • Volume:
    35
  • Issue:
    1
  • Status:
    Published
  • Print ISSN:
    0278-0062
Abstract
This work provides an insight into positron emission tomography (PET) joint image reconstruction/motion estimation (JRM) by maximization of the likelihood, where the probabilistic model accounts for warped attenuation. Our analysis shows that maximum-likelihood (ML) JRM returns the same reconstructed gates for any attenuation map ( -map) that is a deformation of a given -map, regardless of its alignment with the PET gates. We derived a joint optimization algorithm accordingly, and applied it to simulated and patient gated PET data. We first evaluated the proposed algorithm on simulations of respiratory gated PET/CT data based on the XCAT phantom. Our results show that independently of which -map is used as input to JRM: (i) the warped -maps correspond to the gated -maps, (ii) JRM outperforms the traditional post-registration reconstruction and consolidation (PRRC) for hot lesion quantification and (iii) reconstructed gated PET images are similar to those obtained with gated -maps. This suggests that a breath-held -map can be used. We then applied JRM on patient data with a -map derived from a breath-held high resolution CT (HRCT), and compared the results with PRRC, where each reconstructed PET image was obtained with a corresponding cine-CT gated -map. Results show that JRM with breath-held HRCT achieves similar reconstruction to that using PRRC with cine-CT. This suggests a practical low-dose solution for implementation of motion-corrected respiratory gated PET/CT.
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