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Publication Detail
Molecular engineering of polymersome surface topology.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Ruiz-Pérez L, Messager L, Gaitzsch J, Joseph A, Sutto L, Gervasio FL, Battaglia G
  • Publication date:
    15/04/2016
  • Pagination:
    e1500948
  • Journal:
    Science advances
  • Volume:
    2
  • Issue:
    4
  • Medium:
    Electronic-eCollection
  • Language:
    eng
  • Addresses:
    Department of Chemistry, University College London, 20 Gordon Street, WC1H 0AJ London, UK.
Abstract
Biological systems exploit self-assembly to create complex structures whose arrangements are finely controlled from the molecular to mesoscopic level. We report an example of using fully synthetic systems that mimic two levels of self-assembly. We show the formation of vesicles using amphiphilic copolymers whose chemical nature is chosen to control both membrane formation and membrane-confined interactions. We report polymersomes with patterns that emerge by engineering interfacial tension within the polymersome surface. This allows the formation of domains whose topology is tailored by chemical synthesis, paving the avenue to complex supramolecular designs functionally similar to those found in viruses and trafficking vesicles.
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