Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Minimal cognitive impairment in UK HIV positive men who have sex with men: Effect of case definitions, and comparison with the general population and HIV negative men
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article in Press
  • Authors:
    McDonnell J, Haddow L, Daskalopoulou M, Lampe F, Speakman A, Gilson R, Phillips A, Sherr L, Wayal S, Harrison J, Antinori A, Maruff P, Schembri A, Johnson M, Collins S, Rodger A
  • Publication date:
  • Journal:
    Journal of Acquired Immune Deficiency Syndromes
  • Status:
  • Print ISSN:
BACKGROUND: To determine the prevalence of neurocognitive impairment (NCI) in UK HIV positive and HIV negative men who have sex with men (MSM). METHODS: HIV positive (HIV+) and negative participants were recruited to a cross-sectional study from two London clinics and completed computer-assisted neuropsychological tests and questionnaires of depression, anxiety and activities of daily living. Published definitions of HIV-Associated Neurocognitive Disorders (HAND), and Global Deficit Scores (GDS), were used. Age- and education-adjusted NP test scores were directly compared with reference population data. RESULTS: 248 HIV+ and 45 HIV-negative MSM participated. In the HIV+ group, median time since diagnosis was 9.4 years, median CD4+ count was 550 cells/mm, and 88% were on antiretroviral therapy (ART). Prevalence of HAND was 21.0% in HIV+ MSM (13.7% asymptomatic neurocognitive impairment [ANI], 6.5% minor neurocognitive disorder [MND] and 0.8% HIV-associated dementia [HAD]). Using a GDS threshold of 0.5, the prevalence of NCI was 31.5% (when averaged over 5 neuropsychological domains) and 40.3% (over 10 neuropsychological test scores). These results were not significantly different from the HIV-negative study sample. No consistent pattern of impairment was seen in HIV+ patients relative to male general population data (n=380). CONCLUSION: We found a prevalence of HAND and degree of impairment on neuropsychological testing of HIV+ MSM that could represent a normal population distribution. These findings suggest that NCI may be overestimated in HIV+ MSM, and that the attribution of NCI to HIV infection implied by the term HAND requires revision.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Lic ense, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/3.0.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers Show More
Infection & Population Health
Infection & Population Health
Infection & Population Health
Infection & Population Health
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by