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Publication Detail
Inherited mtDNA variations are not strong risk factors in human prion disease
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Hudson G, Uphill J, Hummerich H, Blevins J, Gambetti P, Zerr I, Collinge J, Mead S, Chinnery PF
  • Publication date:
    01/10/2015
  • Pagination:
    2908.e1, 2908.e3
  • Journal:
    Neurobiology of Aging
  • Volume:
    36
  • Issue:
    10
  • Status:
    Published
  • Print ISSN:
    0197-4580
Abstract
© 2015 Elsevier Inc. Aside from variation in the prion protein gene, genetic risk factors for sporadic Creutzfeldt-Jakob disease remain elusive. Given emerging evidence implicating mitochondrial dysfunction in the pathogenesis of the disorders, we studied the role of inherited mitochondrial DNA variation in a 2255 sporadic prion disease cases and 3768 controls. Our analysis indicates that inherited mitochondrial DNA variation does not have a major role in the risk of developing the disorder.
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UCL Researchers
Author
MRC Prion Unit at UCL
Author
MRC Prion Unit at UCL
Author
MRC Prion Unit at UCL
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