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Publication Detail
Second-order motion-compensated spin echo diffusion tensor imaging of the human heart.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Stoeck CT, von Deuster C, Genet M, Atkinson D, Kozerke S
  • Publication date:
    04/2016
  • Pagination:
    1669, 1676
  • Journal:
    Magn Reson Med
  • Volume:
    75
  • Issue:
    4
  • Status:
    Published
  • Country:
    United States
  • Language:
    eng
  • Keywords:
    diffusion tensor imaging, in vivo cardiac DTI, myocardial microstructure, spin-echo, Cardiac Imaging Techniques, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging, Heart, Humans, Signal Processing, Computer-Assisted
Abstract
PURPOSE: Myocardial microstructure has been challenging to probe in vivo. Spin echo-based diffusion-weighted sequences allow for single-shot acquisitions but are highly sensitive to cardiac motion. In this study, the use of second-order motion-compensated diffusion encoding was compared with first-order motion-compensated diffusion-weighted imaging during systolic contraction of the heart. METHODS: First- and second-order motion-compensated diffusion encoding gradients were incorporated into a triggered single-shot spin echo sequence. The effect of contractile motion on the apparent diffusion coefficients and tensor orientations was investigated in vivo from basal to apical level of the heart. RESULTS: Second-order motion compensation was found to increase the range of systolic trigger delays from 30%-55% to 15%-77% peak systole at the apex and from 25%-50% to 15%-79% peak systole at the base. Diffusion tensor analysis yielded more physiological transmural distributions when using second-order motion-compensated diffusion tensor imaging. CONCLUSION: Higher-order motion-compensated diffusion encoding decreases the sensitivity to cardiac motion, thereby enabling cardiac DTI over a wider range of time points during systolic contraction of the heart.
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