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Publication Detail
B Cell Activation and B Cell Tolerance
  • Publication Type:
  • Authors:
    Mauri C, Reddy V, Blair PA
  • Publication date:
  • Pagination:
    147, 158
  • ISBN-13:
  • Status:
  • Book title:
    The Autoimmune Diseases: Fifth Edition
Upon exposure to an antigen, whether microbial or following vaccination, naïve B cells undergo a series of activation and maturation steps that drive their differentiation into memory or plasma cells, and result in the production of antibodies that target the invading organism. Upon re-encounter with an antigen, both plasma and memory B cells promptly respond by releasing antibodies. The stochastic nature of B cell development yields cells with a diverse repertoire, a significant proportion of which recognize self-antigen at the earliest stages of differentiation. However, the immune system has evolved an exquisite series of checkpoints that discriminate self- from non-self-antigens, thus preventing undesirable activation of autoreactive B cells. In this chapter we describe the events and mechanisms by which B cells achieve a fine balance between activation and tolerance and how defects in the maintenance of this balance can increase the risk of autoimmunity. © 2014 Elsevier Inc. All rights reserved.
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