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Publication Detail
Belimumab in systemic lupus erythematosus
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Review
  • Authors:
    Vilas-Boas A, Morais SA, Isenberg DA
  • Publication date:
    01/01/2015
  • Journal:
    RMD Open
  • Volume:
    1
  • Issue:
    1
  • Status:
    Published
Abstract
Systemic lupus erythematosus (SLE) is one of the most challenging autoimmune disorders with a complex pathophysiology and diverse clinical presentation. Many drugs have been used to treat SLE with suboptimal results, especially in patients with moderate-to-severe disease. Belimumab is the first biological drug to be approved for the treatment of SLE in more than 50 years. This monoclonal antibody blocks B-cell activating factor, a cytokine important for B-cell differentiation and survival. In this review we focus on the activity of belimumab in patients with SLE and discuss the controversies of its use.
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