UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Abnormal motor cortex excitability in preclinical and very early Huntington's disease.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Schippling S, Schneider SA, Bhatia KP, M√ľnchau A, Rothwell JC, Tabrizi SJ, Orth M
  • Publication date:
    06/2009
  • Pagination:
    959, 965
  • Journal:
    Biological Psychiatry
  • Volume:
    65
  • Issue:
    11
  • Print ISSN:
    0006-3223
  • Keywords:
    Adult, AFFERENT, AFFERENT INHIBITION, Analysis of Variance, article, Brain Mapping, CAG REPEAT, CEREBRAL CORTEX, CORTEX, CORTICAL EXCITABILITY, DISEASE, DISORDERS, DURATION, DYSFUNCTION, Electric Stimulation, Electromyography, Evoked Potentials, Motor, EXCITABILITY, Female, GENE, HEALTHY, HUMANS, Huntington Disease, Huntington's disease, INHIBITION, intracortical inhibition, INVOLVEMENT, LATENCY, MAGNETIC STIMULATION, Male, median nerve, Methods, Middle Aged, MOTOR, MOTOR CORTEX, motor evoked potential, MOTOR EVOKED POTENTIALS, Movement, MOVEMENT DISORDER, MOVEMENT DISORDERS, Neural Conduction, Neurology, ONSET, PATHOLOGY, pathophysiology, PATIENT, patients, physiology, physiopathology, POTENTIALS, RATING SCALE, Reaction Time, RECRUITMENT, Rest, SCALE, SILENT PERIOD, Spreading Cortical Depression, STIMULATION, threshold, THRESHOLDS, TIME, TMS, transcranial magnetic stimulation
Abstract
BACKGROUND: In Huntington's disease (HD), the cerebral cortex is involved early in the disease process. The study of cortical excitability can therefore contribute to understanding HD pathophysiology. METHODS: With transcranial magnetic stimulation (TMS) we examined motor cortex excitability in 8 premanifest HD gene carriers, 8 very early symptomatic HD patients, and 22 healthy control subjects. Electrophysiological measures were correlated with the clinical stage of HD to identify motor cortical dysfunction before overt clinical disease onset. RESULTS: Premanifest and early manifest HD patients had higher resting and active motor cortex thresholds than control subjects (p = .024). At rest, recruitment of motor evoked potentials was more gradual in both patient groups than in control subjects (p = .001). When active, recruitment and the duration of the cortical silent period were similar in all groups. There was a tendency for short interval intra-cortical inhibition to have a higher threshold in all patients taken together but not in each group separately. Short latency afferent inhibition (SAI) was reduced in early manifest patients compared with control subjects and premanifest patients (p < .001) and in contrast to all other measures was inversely associated with estimated time to onset (p = .013, adjusted R(2) = .32) and the Unified Huntington's Disease Rating Scale motor score (p = .001, adjusted R(2) = .5). A combination of age, CAG repeat length, and SAI strongly predicted the Unified Huntington's Disease Rating Scale motor score (p = .001, adjusted R(2) = .68). CONCLUSIONS: Our findings add to the evidence for early cortical involvement in HD possibly before HD signs appear
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Clinical and Movement Neurosciences
Author
Clinical and Movement Neurosciences
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by