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Publication Detail
Deficiency in serum immunoglobulin (Ig)M predisposes to development of IgG autoantibodies
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Ehrenstein MR, Cook HT, Neuberger MS
  • Publication date:
    03/04/2000
  • Pagination:
    1253, 1258
  • Journal:
    Journal of Experimental Medicine
  • Volume:
    191
  • Issue:
    7
  • Print ISSN:
    0022-1007
  • Keywords:
    age, Animal, antibodies, Antibody, ANTIGEN, Antigens, As, Association, Autoantibodies, Autoantigens, Autoimmunity, biology, Blood, Cell Line, deficiency, DEPOSITION, development, EXPOSURE, HIGH-AFFINITY, HUMANS, IgG, Igm, immune, IMMUNE RESPONSE, IMMUNE-RESPONSE, Immunoglobulins, mu-Chain, immunology, Lipopolysaccharide, mice, Mice, Inbred C57BL, Molecular, Molecular Biology, renal, Research, response, serum, STATE, STATES, Support, Non-U.S.Gov't, United States
  • Addresses:
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
  • Notes:
    UI - 20213467 LA - eng RN - 0 (Autoantibodies) RN - 0 (IgG) RN - 0 (IgM) RN - 0 (Immunoglobulins, mu-Chain) PT - Journal Article DA - 20000608 IS - 0022-1007 SB - IM CY - UNITED STATES JC - I2V
Abstract
Serum immunoglobulin (Ig)M provides the initial response to foreign antigen and plays a regulatory role in subsequent immune response development, accelerating the production of high-affinity IgG. Here we show that mice deficient in serum IgM have an increased propensity to spontaneous autoimmunity as judged by the development with age of serum IgG anti-DNA antibodies and the renal deposition of IgG and complement. They also exhibit augmented anti-DNA IgG production on exposure to lipopolysaccharide. Thus, deficiency in serum IgM leads to diminished responsiveness to foreign antigens but increased responsiveness to self- a paradoxical association reminiscent of that described in humans deficient in complement or IgA.We wondered whether serum IgM might play an analogous role with regard to the response to self-antigens. However, here-in contrast to the sluggish response to foreign antigens- we find that deficiency in serum IgM actually predisposes to the development of IgG antibodies to autoantigens
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