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Publication Detail
Live observation of fission yeast meiosis in recombination-deficient mutants: A study on achiasmate chromosome segregation
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Molnar M, Bähler J, Kohli J, Hiraoka Y
  • Publication date:
  • Pagination:
    2843, 2853
  • Journal:
    Journal of Cell Science
  • Volume:
  • Issue:
  • Status:
  • Print ISSN:
Regular segregation of homologous chromosomes during meiotic divisions is essential for the generation of viable progeny. In recombination-proficient organisms, chromosome disjunction at meiosis I generally occurs by chiasma formation between the homologs (chiasmate meiosis). We have studied meiotic stages in living rec8 and rec7 mutant cells of fission yeast, with special attention to prophase and the first meiotic division. Both rec8 and rec7 are early recombination mutants, and in rec7 mutants, chromosome segregation at meiosis I occurs without any recombination (achiasmate meiosis). Both mutants showed distinct irregularities in nuclear prophase movements. Additionally, rec7 showed an extended first division of variable length and with single chromosomes changing back and forth between the cell poles. Two other early recombination deficient mutants (rec14 and rec15) showed very similar phenotypes to rec7 during the first meiotic division, and the fidelity of achiasmate chromosome segregation slightly exceeded the expected random level. We discuss possible regulatory mechanisms of fission yeast to deal with achiasmate chromosome segregation.
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