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Publication Detail
Restoring motor function using optogenetics and neural engraftment
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Bryson JB, Barchellos Machado C, Lieberam I, Greensmith L
  • Publisher:
  • Publication date:
  • Journal:
    Current Opinion in Biotechnology
  • Status:
  • Print ISSN:
Controlling muscle function is essential for human behaviour and survival, thus, impairment of motor function and muscle paralysis can severely impact quality of life and may be immediately life-threatening, as occurs in many cases of traumatic spinal cord injury (SCI) and in patients with amyotrophic lateral sclerosis (ALS). Repairing damaged spinal motor circuits, in either SCI or ALS, currently remains an elusive goal. Therefore alternative strategies are needed to artificially control muscle function and thereby enable essential motor tasks. This review focuses on recent advances towards restoring motor function, with a particular focus on stem cell-derived neuronal engraftment strategies, optogenetic control of motor function and the potential future translational application of these approaches.
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Department of Neuromuscular Diseases
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