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Publication Detail
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Okbay A, Baselmans BML, De Neve JE, Turley P, Nivard MG, Fontana MA, Meddens SFW, Linnér RK, Rietveld CA, Derringer J, Gratten J, Lee JJ, Liu JZ, De Vlaming R, SAhluwalia T, Buchwald J, Cavadino A, Frazier-Wood AC, Furlotte NA, Garfield V, Geisel MH, Gonzalez JR, Haitjema S, Karlsson R, Der Laan SW, Ladwig KH, Lahti J, Van Der Lee SJ, Lind PA, Liu T, Matteson L, Mihailov E, Miller MB, CMinica C, MNolte I, Mook-Kanamori D, Van Der Most PJ, Oldmeadow C, Qian Y, Raitakari O, Rawal R, Realo A, Rueedi R, Schmidt B, Smith AV, Stergiakouli E, Tanaka T, Taylor K, Wedenoja J, Wellmann J, Westra HJ, MWillems S, Zhao W, Study LLC, Amin N, Bakshi A, Boyle PA, Cherney S, Cox SR, Davies G, Davis OSP, Ding J, Direk N, Eibich P, Emeny RT, Fatemifar G, Faul JD, Ferrucci L
  • Publication date:
    18/04/2016
  • Pagination:
    624, 633
  • Journal:
    Nature Genetics
  • Volume:
    48
  • Issue:
    6
  • Status:
    Published
  • Print ISSN:
    1061-4036
Abstract
© 2016 Nature America, Inc.Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (P = 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
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