Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Changes in cortical potential associated with modulation of peripheral sympathetic activity in patients with epilepsy
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Nagai Y, Critchley HD, Rothwell JC, Duncan JS, Trimble MR
  • Publication date:
  • Pagination:
    84, 92
  • Journal:
    Psychosomatic Medicine
  • Volume:
  • Issue:
  • Print ISSN:
  • Keywords:
    activity, Adolescent, Adult, AMPLITUDE, ANTICONVULSANT, Anticonvulsants, Arousal, article, Biofeedback (Psychology), Contingent Negative Variation, CORTICAL EXCITABILITY, CORTICAL POTENTIALS, Drug Resistance, drug therapy, effect, Electroencephalography, EPILEPSY, Evoked Potentials, EXCITABILITY, Female, FREQUENCY, Galvanic Skin Response, HUMANS, LONG TERM, Male, Methods, Middle Aged, MODULATION, PATIENT, patients, physiology, physiopathology, POTENTIALS, psychology, Reaction Time, seizure, SKIN, SLOW CORTICAL POTENTIALS, sympathetic nervous system, therapeutic use, therapy, treatment, Treatment Outcome, Volition, Young Adult
OBJECTIVES: To examine the immediate and sustained effects of volitional sympathetic modulation, using galvanic skin response (GSR) biofeedback training on cortical excitability in patients with drug-resistant epilepsy. METHODS: Ten patients undertook 12 sessions of GSR biofeedback training over 1 month, during which they were trained to increase sympathetic arousal, using GSR biofeedback. Contingent negative variation (CNV) (a slow cortical potential reflecting cortical arousal and excitability) and the related post imperative negative variation (PINV) were quantified before and after biofeedback treatment. RESULTS: A significant reduction in CNV amplitude was observed in both the short-term (within the first session, after 10 minutes of GSR biofeedback) and long-term (sustained after 12 training sessions). Specifically, the change in baseline CNV amplitude after the 12 training sessions correlated with a percentage reduction in seizure frequency. Furthermore, changes in baseline amplitude of the PINV also correlated with seizure reduction. CONCLUSIONS: Our findings demonstrate that behavioral enhancement of peripheral sympathetic tone (GSR) is associated with modulation of indices of cortical excitability. Moreover, GSR biofeedback training over repeated sessions was associated with a chronic baseline reduction in slow cortical potentials and concurrent therapeutic improvement
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Clinical & Experimental Epilepsy
Clinical and Movement Neurosciences
UCL Queen Square Institute of Neurology
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by