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Publication Detail
Ageing within the hematopoietic stem cell compartment.
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Pearce D, Bonnet D
  • Publication date:
  • Pagination:
    54, 57
  • Journal:
    Mech Ageing Dev
  • Volume:
  • Issue:
  • Print ISSN:
  • Keywords:
    Aged, Aging, Apoptosis, Hematopoietic Stem Cells, Homeostasis, Humans
  • Addresses:
    Hematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK.
  • Notes:
    As we humans are far too aware, all mammals have a finite lifespan. Apart from basic longevity, age is also a major risk factor for most cancers and diseases. Since adult stem cells are responsible for maintaining tissue homeostasis throughout an organism's lifetime, an attractive theory is that ageing-related phenotypes might be, at least in part, due to an alteration in the number and/or function of tissue stem cells. Here, we have focused on hematopoietic stem cells as they are one of the best-characterized adult stem cell populations, and have been extensively studied for the consequences of ageing in vivo and in vitro.
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