UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data shown on the profile page to:

http://www.ucl.ac.uk/finance/secure/research/post_award
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Nanodiamond monolayer coating promotes formation of functional neuronal networks
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Thalhammer A, Edgington RJ, Cingolani LA, Schoepfer R, Jackman , R B
  • Publisher:
    Elsevier
  • Publication date:
    2010
  • Pagination:
    2097, 2104
  • Journal:
    Biomaterials
  • Volume:
    31
  • Print ISSN:
    0142-9612
  • Keywords:
    Diamond, electrophysiology, nanoparticle, neural network
Abstract
Nanostructured materials provide a new dimension of interaction with biological systems that takes place on a sub-cellular level with a high degree of specificity. In the field of neuroscience the nanoscale corresponds to the size of synapses; the specific connections between brain cells. In this context, diamond-based materials have attracted much attention due to their extreme mechanical and electrical properties and their chemical inertness. Here the suitability of nanodiamond (ND) monolayers to act as a platform for neuronal growth is investigated. Neurons cultured on various ND-coated substrates perform remarkably well, and similar to those grown on standard protein coated materials with respect to their initial cell attachment, sustained neurite outgrowth, cell-autonomous neuronal excitability and functionality of the resulting electrical networks. ND layering provides an excellent growth substrate on various materials for functional neuronal networks and bypasses the necessity of protein coating, which promises great potential for chronic medical implants
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Authors
Dept of Electronic & Electrical Eng
Neuroscience, Physiology & Pharmacology
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by