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Publication Detail
Electrosprayed Janus Particles for Combined Photo-Chemotherapy.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Sanchez-Vazquez B, Amaral AJ, Yu DG, Pasparakis G, Williams GR
  • Publication date:
    30/09/2016
  • Journal:
    AAPS PharmSciTech
  • Medium:
    Print-Electronic
  • Language:
    eng
  • Addresses:
    UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK.
Abstract
This work is a proof of concept study establishing the potential of electrosprayed Janus particles for combined photodynamic therapy-chemotherapy. Sub-micron-sized particles of polyvinylpyrrolidone containing either an anti-cancer drug (carmofur) or a photosensitiser (rose bengal; RB), and Janus particles containing both in separate compartments were prepared. The functional components were present in the amorphous form in all the particles, and infrared spectroscopy indicated that intermolecular interactions formed between the different species. In vitro drug release studies showed that both carmofur and RB were released at approximately the same rate, with dissolution complete after around 250 min. Cytotoxicity studies were undertaken on model human dermal fibroblasts (HDF) and lung cancer (A549) cells, and the influence of light on cell death explored. Formulations containing carmofur as the sole active ingredient were highly toxic to both cell lines, with or without a light treatment. The RB formulations were non-toxic to HDF when no light was applied, and with photo-treatment caused large amounts of cell death for both A549 and HDF cells. The Janus formulation containing both RB and carmofur was non-toxic to HDF without light, and only slightly toxic with the photo-treatment. In contrast, it was hugely toxic to A549 cells when light was applied. The Janus particles are thus highly selective for cancer cells, and it is hence proposed that such electrosprayed particles containing both a chemotherapeutic agent and photosensitiser have great potential in combined chemotherapy/photodynamic therapy.
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