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Publication Detail
Assessment of patients with primary Sjögren's syndrome-outcome over 10 years using the Sjögren's Syndrome Damage Index
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Krylova L, Isenberg D
  • Publication date:
    05/05/2010
  • Pagination:
    1559, 1562
  • Journal:
    Rheumatology
  • Volume:
    49
  • Issue:
    8
  • Status:
    Published
  • Print ISSN:
    1462-0324
Abstract
Objective: To evaluate the long-term outcome in a cohort of patients with primary SS (PSS) using the recently proposed Sjogren's Syndrome Damage Index. Methods: We reviewed the clinical records of 60 patients attending our Sjögren's clinic at University College London Hospital, who strictly fulfilled the American-European Consensus Group criteria and on whom we had a minimum of 10 years of follow-up (or until death) during this decade. However, we could not retrospectively identify damage in the oral domain as this had not been recorded reliably. Results: Fifty-five per cent of patients in this study had no damage after 10 years of disease-a lower figure than our comparative group of patients with SLE (32.4%). Damage accrual was mostly in the ocular domain, parotid swelling and malignancy categories. There was a 6-fold increase in the 'malignancy damage' compared with the 2-fold increase in the total damage score in PSS. Conclusions: Unlike patients with SLE, it is clear that fewer patients with SS develop permanent damage, even after 10 years of follow-up. These data are thus encouraging but clearly larger numbers of patients need to be assessed. © The Author 2010.
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