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Publication Detail
Recent advances in the treatment of systemic lupus erythematosus
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article in Press
  • Authors:
    Rodriguez-Garcia V, Dias SS, Isenberg D
  • Publication date:
    13/09/2013
  • Journal:
    Bailliere's Best Practice and Research in Clinical Rheumatology
  • Status:
    Accepted
  • Print ISSN:
    1521-6942
Abstract
The survival for patients with systemic lupus erythematosus has improved greatly in the last 50 years. Faster diagnosis, renal dialysis and transplant and better general care (including lowering of blood pressure and treating osteoporosis) have had an important role in this. We have optimised the use of corticosteroids and conventional immunosuppressive drugs, reducing the side effects and improving efficacy. However, the progression to end-stage renal disease has not changed. The advent of targeted therapies using biologic agents has held great promise but because of the design of the trials, the results are disappointing and these drugs are not yet widely accepted. More and better-designed trials are needed. © 2013.
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