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Publication Detail
Assessing vascular response to exercise using a combination of real-time spiral phase contrast MR and noninvasive blood pressure measurements.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Steeden JA, Atkinson D, Taylor AM, Muthurangu V
  • Publication date:
  • Pagination:
    997, 1003
  • Journal:
    J Magn Reson Imaging
  • Volume:
  • Issue:
  • Status:
  • Country:
    United States
  • Language:
  • Keywords:
    Adult, Aorta, Artifacts, Blood Flow Velocity, Blood Pressure, Female, Heart Rate, Hemodynamics, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Phantoms, Imaging, Reproducibility of Results, Time Factors
PURPOSE: To measure the hemodynamic response to exercise using real-time velocity mapping magnetic resonance imaging (MRI), incorporating a high temporal resolution spiral phase contrast (PC) sequence accelerated with sensitivity encoding (SENSE). MATERIALS AND METHODS: Twenty healthy adults underwent MRI at rest and during supine exercise at two different exercise levels. Flow volumes were assessed in the ascending aorta using a spiral SENSE real-time PC sequence. The sequence was validated at rest against a vendor supplied gated PC sequence, and also at rest and during exercise against left ventricular volumes assessed using a radial k-t SENSE real-time sequence. Combining the measured flow volumes with simultaneous oscillometric blood pressure measurements, enabled the noninvasive calculations of systemic vascular resistance (SVR) and arterial compliance (C). RESULTS: Measured flow volumes correlated very well between the sequences at rest and during exercise. Cardiac output (CO) and heart rate were found to significantly increase during exercise, while SVR and C were found to decrease significantly. CONCLUSION: Hemodynamic response to exercise can be accurately quantified using a high temporal resolution spiral SENSE real-time flow imaging. This may allow early detection of hypertension and a greater understanding of the early changes in this condition.
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