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Publication Detail
  • Publication Type:
  • Authors:
    Garavan H, Lingford-Hughes A, Jones T, Morris P, Rothwell J, Williams S
  • Publication date:
  • Pagination:
    285, 314
  • ISBN-13:
  • Status:
  • Book title:
    Drugs and the Future
Functional neuroimaging techniques, particularly functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and single photon emission tomography (SPET), are well suited to the study of drug addiction-including the mechanisms involved in its effects on the brain. These techniques have contributed much in the past decade or so toward the understanding of this most challenging social issue. But research effort in this area is not commensurate to the importance of the problem. This chapter reviews the application of neuroimaging to the study of drug addiction, beginning with the defining pharmacology and studies of craving before considering the more cognitive aspects. The availability of small imaging systems, particularly for magnetic resonance imaging (MRI), but also increasingly for PET and SPET, and in a few cases for combined MRI/PET, enables noninvasive methodologies to be applied to animal models. The development of PET as a molecular imaging tool is also considered in the chapter. Future developments in MRI, fMRI and their sister technique, magnetic resonance spectroscopy (MRS), are also elaborated in the chapter. Although the vast majority of neuroimaging studies are based on fMRI, PET and SPET, these techniques lack temporal resolution. A brief discussion of this issue is included in the final section of the chapter. © 2007 Elsevier Inc. All rights reserved.
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