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Publication Detail
Functional involvement of cerebral cortex in duchenne muscular dystrophy
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Di Lazzaro V, Restuccia D, Servidei S, Nardone R, Oliviero A, Profice P, Mangiola F, Tonali P, Rothwell JC
  • Publication date:
    01/01/1998
  • Pagination:
    662, 664
  • Journal:
    Muscle and Nerve
  • Volume:
    21
  • Issue:
    5
  • Status:
    Published
  • Print ISSN:
    0148-639X
Abstract
Transcranial stimulation was performed in 4 patients with Duchenne muscular dystrophy and 4 control subjects. The patients' central motor conduction time was normal. The threshold for evoking electromyographic responses using electrical anodal stimulation was the same in both groups, but the threshold for stimulation with a circular magnetic coil at the vertex was higher in the patients. This is compatible with reduced cortical excitability that may be related to the deficiency of brain synaptic dystrophin.
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