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Publication Detail
Thrombocytopenia in the Antiphospholipid Syndrome
Thrombocytopenia is one of the most common noncriteria haematological manifestations of antiphospholipid syndrome (APS). It occurs in 20–53% in patients with primary and secondary APS. However, the pathogenesis of thrombocytopenia in patients with APS is still unclear. The platelet reduction is often mild, without bleeding complications and rarely requires treatment. When anticoagulation is necessary, it may be difficult to manage because of the increased bleeding risk. If thrombocytopenia is severe, owing to shared characteristics with idiopathic thrombocytopenic purpura, similar treatment is usually recommended. Nevertheless, the optimal treatment of APS-associated thrombocytopenia is not fully established, due to a lack of randomized, controlled trials. This chapter discusses the significance, pathogenesis, and management of thrombocytopenia associated with APS, and also briefly review the other conditions that may cause thrombocytopenia and have some similarities with APS.
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