UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
The effect of transcranial direct current stimulation on motor sequence learning and upper limb function after stroke.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Fleming MK, Rothwell JC, Sztriha L, Teo JT, Newham DJ
  • Publication date:
    31/03/2017
  • Journal:
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
  • Medium:
    Print-Electronic
  • Print ISSN:
    1388-2457
  • Language:
    eng
  • Addresses:
    Centre of Human and Aerospace Physiological Sciences, King's College London, UK. Electronic address: melanie.fleming@kcl.ac.uk.
Abstract
To assess the impact of electrode arrangement on the efficacy of tDCS in stroke survivors and determine whether changes in transcallosal inhibition (TCI) underlie improvements.24 stroke survivors (3-124months post-stroke) with upper limb impairment participated. They received blinded tDCS during a motor sequence learning task, requiring the paretic arm to direct a cursor to illuminating targets on a monitor. Four tDCS conditions were studied (crossover); anodal to ipsilesional M1, cathodal to contralesional M1, bihemispheric, sham. The Jebsen Taylor hand function test (JTT) was assessed pre- and post-stimulation and TCI assessed as the ipsilateral silent period (iSP) duration using transcranial magnetic stimulation.The time to react to target illumination reduced with learning of the movement sequence, irrespective of tDCS condition (p>0.1). JTT performance improved after unilateral tDCS (anodal or cathodal) compared with sham (p<0.05), but not after bihemispheric (p>0.1). There was no effect of tDCS on change in iSP duration (p>0.1).Unilateral tDCS is effective for improving JTT performance, but not motor sequence learning.This has implications for the design of future clinical trials.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Clinical and Movement Neurosciences
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by