UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at http://www.ucl.ac.uk/finance/research/post_award/post_award_contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
THE SMARTTARGET BIOPSY TRIAL: A PROSPECTIVE PAIRED BLINDED TRIAL WITH RANDOMISATION TO COMPARE VISUAL-ESTIMATION AND IMAGE-FUSION TARGETED PROSTATE BIOPSIES
  • Publication Type:
    Conference presentation
  • Publication Sub Type:
    Presentation
  • Authors:
    Donaldson I, Hamid S, Barratt D, Hu Y, Rodell R, Villarini B, Bonmati E, Martin P, Hawkes D, McCartan N, Potyka I, Williams N, Brew-Graves C, Moore C, Emberton M, Ahmed H
  • Date:
    13/05/2017
  • Status:
    Published
  • Name of Conference:
    American Urological Association (AUA) 2017 Annual Meeting
  • Conference place:
    Boston, MA, USA
  • Conference start date:
    12/05/2017
  • Conference finish date:
    16/05/2017
  • Language:
    English
  • Conference URL:
Abstract
INTRODUCTION AND OBJECTIVES: Multi-parametric MRI targeted prostate biopsies can improve detection of clinically significant prostate cancer and decrease the diagnosis of clinically insignificant cancers. There is debate whether visual estimated targeting is sufficient or whether image-fusion software is required. We conducted an ethics committee approved, prospective, blinded, paired validating clinical trial of visual estimated targeted biopsies compared to non-rigid MR/US image-fusion using an academically developed fusion system (SmartTarget®). METHODS: 141 men requiring targeted transperineal bi- opsies for accurate risk stratification were enrolled following written informed consent (August2014-September2016). Entry required prior trans-rectal ultrasound biopsy, a discrete lesion on mpMRI (PIRADS 3-5) and no previous prostate cancer treatment. All men underwent a targeted transperineal biopsy of a single lesion using visual estimation (3 cores) and image-fusion (3 cores). Two different urologists independently conducted the targeting strate- gies with each urologist assigned a strategy and order by rando- mised. Only one urologist was permitted to be present for each biopsy strategy and did not communicate with the other about any aspect of the procedure (blinded). 14 urologists of varying levels of experience participated. All were competent in transperineal tar- geting. UCL definition 2 clinically significant prostate cancer was used as the target condition for the primary outcome (>/¼ G3+4 and or MCCL >/¼ 4mm). RESULTS: 129 men completed both biopsy strategies. Median age (IQR) was 65 years (58-70) and median PSA was 8.5ng/ml (5.6- 12.1). 94 (72.8%) had clinically significant prostate cancer; 81/94 (86.2%) were identified on visual estimation targeting and 81/94 (86.2%) on image-fusion targeting. Fusion biopsy and visual estimation targeting each identified clinically significant cancers that the other missed, 13 and 13 respectively. We found no statistically significant difference between visual estimation and image-fusion (McNe- mar, p¼1.00). CONCLUSIONS: Our prospective, paired blinded trial demonstrates that there is no overall difference in detection of clinically significant prostate cancer between visual estimation and image-fusion targeted biopsies. Our results suggest that both techniques should be used together for optimal cancer detection.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers Show More
Author
Dept of Med Phys & Biomedical Eng
Author
Dept of Med Phys & Biomedical Eng
Author
Metabolism & Experi Therapeutics
Author
Faculty of Medical Sciences
Author
Dept of Med Phys & Biomedical Eng
Author
Dept of Med Phys & Biomedical Eng
Author
Department of Targeted Intervention
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by