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Publication Detail
SNCA variants are associated with increased risk for multiple system atrophy.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Scholz SW, Houlden H, Schulte C, Sharma M, Li A, Berg D, Melchers A, Paudel R, Gibbs JR, Simon-Sanchez J, Paisan-Ruiz C, Bras J, Ding J, Chen H, Traynor BJ, Arepalli S, Zonozi RR, Revesz T, Holton J, Wood N, Lees A, Oertel W, W├╝llner U, Goldwurm S, Pellecchia MT, Illig T, Riess O, Fernandez HH, Rodriguez RL, Okun MS, Poewe W, Wenning GK, Hardy JA, Singleton AB, Del Sorbo F, Schneider S, Bhatia KP, Gasser T
  • Publication date:
    05/2009
  • Pagination:
    610, 614
  • Journal:
    Ann Neurol
  • Volume:
    65
  • Issue:
    5
  • Status:
    Published
  • Country:
    United States
  • Language:
    eng
  • Keywords:
    Female, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Multiple System Atrophy, Odds Ratio, Polymorphism, Single Nucleotide, Risk, alpha-Synuclein
Abstract
To test whether the synucleinopathies Parkinson's disease and multiple system atrophy (MSA) share a common genetic etiology, we performed a candidate single nucleotide polymorphism (SNP) association study of the 384 most associated SNPs in a genome-wide association study of Parkinson's disease in 413 MSA cases and 3,974 control subjects. The 10 most significant SNPs were then replicated in additional 108 MSA cases and 537 controls. SNPs at the SNCA locus were significantly associated with risk for increased risk for the development of MSA (combined p = 5.5 x 10(-12); odds ratio 6.2) [corrected].
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Neurodegenerative Diseases
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Clinical and Movement Neurosciences
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Department of Neuromuscular Diseases
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Clinical and Movement Neurosciences
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Clinical and Movement Neurosciences
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Neurodegenerative Diseases
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Neurodegenerative Diseases
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