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Publication Detail
Estimation of optical pathlength through tissue from direct time of flight measurement.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Delpy DT, Cope M, van der Zee P, Arridge S, Wray S, Wyatt J
  • Publication date:
    12/1988
  • Pagination:
    1433, 1442
  • Journal:
    Phys Med Biol
  • Volume:
    33
  • Issue:
    12
  • Status:
    Published
  • Country:
    England
  • Print ISSN:
    0031-9155
  • Language:
    eng
  • Keywords:
    Animals, Brain, Light, Models, Biological, Monte Carlo Method, Rats, Rats, Inbred Strains, Transillumination
Abstract
Quantitation of near infrared spectroscopic data in a scattering medium such as tissue requires knowledge of the optical pathlength in the medium. This can now be estimated directly from the time of flight of picosecond length light pulses. Monte Carlo modelling of light pulses in tissue has shown that the mean value of the time dispersed light pulse correlates with the pathlength used in quantitative spectroscopic calculations. This result has been verified in a phantom material. Time of flight measurements of pathlength across the rat head give a pathlength of 5.3 +/- 0.3 times the head diameter.
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