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Publication Detail
Diversification and selection mechanisms for the production of protein repertoires: lessons from the immune system
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Neuberger MS, Sale JE, Cumbers SJ, Jolly CJ, Bemark MP, Ehrenstein MR, Lanoue A, Bruggemann M, Batista FD, Davies SL, Williams GT
  • Publication date:
    01/2000
  • Pagination:
    53, 60
  • Journal:
    Applied Biochemistry and Biotechnology
  • Volume:
    83
  • Issue:
    1-3
  • Print ISSN:
    0885-4513
  • Keywords:
    Animal, antibodies, Antibodies, Monoclonal, Antibody, Antibody Affinity, Antibody Diversity, Antibody Specificity, Australia, biology, biosynthesis, Cell Line, DIVERSITY, formation, Gene Rearrangement, B-Lymphocyte, GENERATION, Genes, Immunoglobulin, genetics, immune, Immune System, IMMUNOGLOBULIN, in vitro, in vivo, In-vitro, in-vivo, MECHANISM, mechanisms, mice, Mice, Transgenic, Molecular, Molecular Biology, Mutation, novel, phase, PHASE-I, process, processes, PROTEIN, REPERTOIRE, Research, Review, selection, Selection (Genetics), STATE, STATES, SYSTEM, United States
  • Addresses:
    Medical Research Council Laboratory of Molecular Biology, Cambridge, NSW, Australia. msn@mrc-lmb.cam.ac.uk
  • Notes:
    UI - 20285224 LA - eng RN - 0 (Antibodies, Monoclonal) PT - Journal Article PT - Review PT - Review, Tutorial DA - 20000828 IS - 0273-2289 SB - IM CY - UNITED STATES JC - 6KJ
Abstract
The physiological mechanism for producing antigen-specific antibodies is based on a two-phase neo-Darwinian process: the first phase consists of diversity generation (formation of the repertoire), and the second phase is antigen-mediated selection. In this article, we consider how the natural immunoglobulin gene-diversification processes can be exploited both in vivo and in vitro in order to allow the generation of novel antibody (and heterologous protein) repertoires
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