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Publication Detail
Memory in the B-cell compartment: antibody affinity maturation
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Neuberger MS, Ehrenstein MR, Rada C, Sale J, Batista FD, Williams G, Milstein C
  • Publication date:
    29/03/2000
  • Pagination:
    357, 360
  • Journal:
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • Volume:
    355
  • Issue:
    1395
  • Print ISSN:
    0962-8436
  • Keywords:
    AFFINITIES, affinity, Animal, antibodies, Antibody, Antibody Affinity, ANTIGEN, ARM, B-Lymphocytes, biology, cell, Class, COMPARTMENT, GENE, GENERATION, genetic, immune, Immune System, IMMUNOGLOBULIN, Immunoglobulin Class Switching, IMMUNOGLOBULIN G, Immunologic Memory, immunology, interaction, maturation, memory, Molecular, Molecular Biology, process, processes, QUALITY, Receptor, Research, response, Review, SYSTEM, UK
  • Addresses:
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK. msn@mrc-lmb.cam.ac.uk
  • Notes:
    UI - 20252028 LA - eng PT - Journal Article PT - Review PT - Review, Tutorial DA - 20000628 IS - 0962-8436 SB - IM CY - ENGLAND JC - P5Z
Abstract
In the humoral arm of the immune system, the memory response is not only more quickly elicited and of greater magnitude than the primary response, but it is also different in quality. In the recall response to antigen, the antibodies produced are of higher affinity and of different isotype (typically immunoglobulin G rather than immunoglobulin M). This maturation rests on the antigen dependence of B- cell maturation and is effected by programmed genetic modifications of the immunoglobulin gene loci. Here we consider how the B-cell response to antigen depends on the affinity of the antigen receptor interaction. We also compare and draw parallels between the two processes, which underpin the generation of secondary-response antibodies: V gene somatic hypermutation and immunoglobulin heavy-chain class switching
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