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Publication Detail
Atomic Force Microscopy of Biological Samples
  • Publication Type:
    Journal article
  • Authors:
    Frederix PLTM, Hoogenboom BW, Fotiadis D, Müller DJ, Engel A
  • Publisher:
    Springer Science and Business Media LLC
  • Publication date:
  • Pagination:
    449, 455
  • Journal:
    MRS Bulletin
  • Volume:
  • Issue:
  • Status:
  • Print ISSN:
  • Language:
AbstractThe atomic force microscope (AFM) allows biomolecules to be observed and manipulated under native conditions. It produces images with an outstanding signal-to-noise ratio and addresses single molecules while the sample is in a buffer solution. Progress in sample preparation and instrumentation has led to topographs that reveal subnanometer details and the surface dynamics of biomolecules. Tethering single molecules between a support and a retracting AFM tip produces force–extension curves, giving information about the mechanical stability of secondary structural elements. For both imaging and force spectroscopy, the cantilever and its tip are critical:the mechanical properties of the cantilever dictate the force sensitivity and the scanning speed, whereas the tip shape determines the achievable lateral resolution.
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