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Publication Detail
Mitochondria as organizers of the cellular ca2+ signaling network
  • Publication Type:
  • Authors:
    Szabadkai G, Duchen MR
  • Publication date:
  • Pagination:
    963, 972
  • Volume:
  • ISBN-13:
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  • Book title:
    Handbook of Cell Signaling, 2/e
Mitochondria have emerged from relative obscurity to take center stage as remarkably autonomous and dynamic cellular organelles that are intimately involved in orchestrating a diverse range of cellular activities. A major focus of current research in mitochondrial biology is to explore the signals generated by mitochondria to regulate gene expression and protein signaling networks. Ca2+ seems to be one of the most significant among these signals. The physiological significance of these pathways has only recently become apparent and is still being refined. Mitochondria will take up and accumulate Ca2+ in all cells studied during the routine events of cellular Ca2+ signaling and the pathway influences both mitochondrial function itself and the spatiotemporal and quantitative characteristics of the cellular Ca2+ signal. Early studies on the impact of Ca2+ accumulation on mitochondrial function led to the characterization of Ca2+ dependent metabolic processes. The capacity to study mitochondria in intact cells that has accompanied the improvements in confocal microscopy has led to the discovery of their dynamic morphological properties, adding a new layer to the plasticity of mitochondrial signaling. Shaping mitochondria seems to be closely interconnected with cellular and mitochondrial Ca2+ signals. This chapter highlights some of the more controversial and novel developments in the field over recent years, and some of the mechanistic, quantitative, and comparative questions that remain. © 2010 Elsevier Inc. All rights reserved.
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