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Publication Detail
A therapeutic trial of milacemide in myoclonus and the stiff-person syndrome.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Brown P, Thompson PD, Rothwell JC, Day BL, Marsden CD
  • Publication date:
  • Pagination:
    73, 75
  • Journal:
    Mov Disord
  • Volume:
  • Issue:
  • Status:
  • Country:
    United States
  • Print ISSN:
  • Language:
  • Keywords:
    Acetamides, Adult, Aged, Anticonvulsants, Female, Humans, Male, Middle Aged, Monoamine Oxidase Inhibitors, Muscle Rigidity, Myoclonus, Neurologic Examination, Spasm, Syndrome
We investigated the therapeutic effects of milacemide in seven patients with myoclonus and three patients with the stiff-person syndrome in an open-label trial. Milacemide was initiated at 800 mg/day and was gradually increased to a maximum dosage of 2,400 mg/day. No significant improvement occurred in the 10 patients.
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