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Publication Detail
Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Krasnow AM, Ford MC, Valdivia LE, Wilson SW, Attwell D
  • Publisher:
    Nature Publishing Group
  • Publication date:
    01/01/2018
  • Journal:
    Nature Neuroscience
  • Print ISSN:
    1097-6256
Abstract
How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+]i in developing oligodendrocytes in vivo, and that myelin sheath elongation is promoted by a high frequency of [Ca2+]i transients and prevented by [Ca2+]i-buffering. Sheath elongation occurs ~1 hour after [Ca2+]i elevation. Sheath shortening is associated with a low frequency of [Ca2+]i transients but with longer duration [Ca2+]i bursts. Thus, [Ca2+]i controls myelin sheath development.
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