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Publication Detail
The variation in anti-ENA characteristics between different ethnic populations with systemic lupus erythematosus over a 10-year period
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Tench CM, Isenberg DA
  • Publication date:
    2000
  • Pagination:
    374, 376
  • Journal:
    Lupus
  • Volume:
    9
  • Issue:
    5
  • Print ISSN:
    0961-2033
  • Keywords:
    adult, antibodies, Antibodies, Antinuclear, Antibody, Antibody Specificity, characteristics, ETHNIC GROUPS, ethnology, Female, FOLLOW UP, Follow-up, Follow-Up Studies, groups, immunology, individuals, Lupus Erythematosus, Systemic, Male, medicine, Middle Age, NUMBER, Patient, patients, Pattern, PATTERNS, population, POPULATIONS, Racial Stocks, Rheumatology, SYSTEMIC LUPUS ERYTHEMATOSUS, UK, VS
  • Addresses:
    Centre for Rheumatology, Department of Medicine, University College London, UK
  • Notes:
    UI - 20342505 LA - eng RN - 0 (Antibodies, Antinuclear) PT - Journal Article DA - 20000808 IS - 0961-2033 SB - IM CY - ENGLAND JC - BRN
Abstract
OBJECTIVE: To assess how anti-ENA characteristics change in patients with systemic lupus erythematosus from different ethnic backgrounds over a 10-year period follow-up study. RESULTS: There were 61 patients, of whom 37 were Caucasian, 12 were Asian and 12 were Afro-Caribbean. At the first available bleed 12/37 (32%) Caucasians were anti-ENA positive compared to 6/12 (50%) Asians and 9/12 (75%) of Afro-Caribbeans (Chi- squared P=0.01 for Caucasian vs Afro-Caribbean) and these proportions remained essentially unchanged after 10 y of follow-up. However, over the 10 y of follow-up anti-ENA patterns did change, with anti-Ro being the commonest antibody pattern to emerge and anti-Ro/La the commonest antibody pattern to disappear. There were 20/37(54%) Caucasians, 1/12(8%) Afro-Caribbeans and 5/12(42%) Asians who remained negative for anti-ENA throughout the 10-year follow-up (Chi-squared P=0.03 for Caucasian vs Afro-Caribbean). CONCLUSION: Anti-ENA were more commonly found in the Afro-Caribbean than the Caucasian population. The commonest patterns of anti-ENA differ between ethnic groups and, over a 10-year period, anti-ENA patterns in individual patients changed in a significant number of individuals. However, Caucasians were more likely to remain anti-ENA negative over 10 y of follow-up than Afro-Caribbeans
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