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Publication Detail
A loss-of-function homozygous mutation in DDX59 implicates a conserved DEAD-box RNA helicase in nervous system development and function.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Salpietro V, Efthymiou S, Manole A, Maurya B, Wiethoff S, Ashokkumar B, Cutrupi MC, Dipasquale V, Manti S, Botia JA, Ryten M, Vandrovcova J, Bello OD, Bettencourt C, Mankad K, Mukherjee A, Mutsuddi M, Houlden H
  • Publication date:
    27/11/2017
  • Journal:
    Human mutation
  • Medium:
    Print-Electronic
  • Status:
    Published
  • Print ISSN:
    1059-7794
  • Language:
    eng
  • Addresses:
    Department of Molecular Neuroscience, Institute of Neurology, University College London, London, WC1N 3BG, UK.
Abstract
We report on a homozygous frameshift deletion in DDX59 (c.185del: p.Phe62fs*13) in a family presenting with oro-facio-digital syndrome phenotype associated to a broad neurological involvement characterized by microcephaly, intellectual disability, epilepsy, and white matter signal abnormalities associated with cortical and sub-cortical ischemic events. DDX59 encodes a DEAD-box RNA helicase and its role in brain function and neurological diseases is unclear. We showed a reduction of mutant cDNA and perturbation of SHH signalling from patient-derived cell lines; furthermore, analysis of human brain gene expression provides evidence that DDX59 is enriched in oligodendrocytes and might act within pathways of leukoencephalopathies associated genes. We also characterized the neuronal phenotype of the Drosophila model using mutant mahe, the homologue of human DDX59, and showed that mahe loss-of-function mutant embryos exhibit impaired development of peripheral and central nervous system. Taken together, our results support a conserved role of this DEAD-box RNA helicase in neurological function. This article is protected by copyright. All rights reserved.
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