Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Biology and therapeutic potential of enteric nervous system stem cells for spinal cord injury
  • Publication Type:
  • Authors:
    Jevans BS
  • Date awarded:
  • Pagination:
    1, 269
  • Supervisors:
    Burns AJ,Thapar N
  • Status:
  • Awarding institution:
    UCL (University College London)
  • Language:
  • Date Submitted:
Spinal cord injury (SCI) is one of the leading and most crippling causes of acquired neurological impairment. It affects around 40,000 individuals in the UK, causing paralysis, multisystem impairment and a reduced life expectancy. This has a devastating impact on quality of life and places stress upon both individuals and healthcare systems. Despite extensive characterization of SCI pathology, there remains no cure. Stem cells offer a potential therapy since they can replace lost neurons, promote axonal regeneration and limit scar formation, but an optimal stem cell source has yet to be found. Enteric neural stem cells (ENSCs) are a possible solution. ENSCs comprise the renewing population of the enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal (GI) tract. ENSCs can be isolated from the GI tract via minimally invasive techniques such as endoscopy, and when transplanted into aneural or dysfunctional gut, are capable of reforming a functional ENS. This thesis assesses the potential of ENSCs as a stem cell source for SCI. Chimeric neural tube grafting was used to fluorescently label chick ENSCs, allowing for isolation and lineage tracing. In vitro characterization revealed neuronal subtypes that were common between ENSCs and spinal cord tissue. Following transplantation into the embryonic chick spinal cord ENSCs survived, differentiated into neurons and formed anatomical bridges across the injury zone. In an adult rat model of SCI, ENSC transplantation was combined with application of chondroitinase ABC (ChABC), a modifier of the inhibitory microenvironment observed within SCI. ENSCs, when transplanted on their own, demonstrated extended survival, differentiated into neurons and bridged the injury site. Combined treatment (ENSCs + ChABC) resulted in a significant improvement in lesion histology, including reduction of the injury cavity, and increased numbers of endogenous axons crossing the injury site. Together, these findings establish ENSCs as a promising alternative stem cell source for SCI.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Developmental Biology & Cancer Dept
Developmental Biology & Cancer Dept
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by