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Publication Detail
Enhancer SINEs Link Pol III to Pol II Transcription in Neurons.
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Policarpi C, Crepaldi L, Brookes E, Nitarska J, French SM, Coatti A, Riccio A
  • Publication date:
  • Pagination:
    2879, 2894
  • Journal:
    Cell reports
  • Volume:
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  • Addresses:
    MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
Spatiotemporal regulation of gene expression depends on the cooperation of multiple mechanisms, including the functional interaction of promoters with distally located enhancers. Here, we show that, in cortical neurons, a subset of short interspersed nuclear elements (SINEs) located in the proximity of activity-regulated genes bears features of enhancers. Enhancer SINEs (eSINEs) recruit the Pol III cofactor complex TFIIIC in a stimulus-dependent manner and are transcribed by Pol III in response to neuronal depolarization. Characterization of an eSINE located in proximity to the Fos gene (FosRSINE1) indicated that the FosRSINE1-encoded transcript interacts with Pol II at the Fos promoter and mediates Fos relocation to Pol II factories, providing an unprecedented molecular link between Pol III and Pol II transcription. Strikingly, knockdown of the FosRSINE1 transcript induces defects of both cortical radial migration in vivo and activity-dependent dendritogenesis in vitro, demonstrating that FosRSINE1 acts as a strong enhancer of Fos expression in diverse physiological contexts.
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