UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Human brain mapping of the motor system after stroke
Abstract
Introduction After stroke, recovery of useful upper-limb function occurs in only 50% of those with significant early paresis, leading to dramatically impaired quality of life and sense of well-being. For most patients, the term “rehabilitation” refers to approaches designed to improve societal participation and quality of life. In this sense, rehabilitation is often successful, but on its own may not take full advantage of the enormous potential for plastic change in the adult human brain, even after focal injury. We have learned much from studying animal models of focal brain injury, but the tools available for studying the working human brain are different to those used in animal models. In human subjects, experiments are performed at the level of neural systems rather than single cells or molecules. Both approaches have something to learn from the other, and it is likely that for a complete understanding of the way the brain responds to injury, both will be helpful. This chapter will concentrate on the ways that functional brain imaging has contributed to our understanding of how the brain responds to injury, and how it might be used in the future to help improve therapeutic approaches to stroke patients with persistent impairment. BOLD signal in cerebrovascular disease: Most functional imaging studies performed in stroke patients have used functional magnetic resonance imaging (fMRI), which relies on the blood oxygen level-dependent (BOLD) signal. The BOLD signal relies on the close coupling between blood flow and metabolism.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Clinical and Movement Neurosciences
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by