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Publication Detail
Integrins and Other Cell Surface Attachment Molecules of Bone Cells
  • Publication Type:
    Chapter
  • Authors:
    Helfrich MH, Stenbeck G, Nesbitt SA, Horton MA
  • Publication date:
    01/12/2008
  • Pagination:
    385, 424
  • Volume:
    1
  • ISBN-13:
    9780123738844
  • Status:
    Published
  • Book title:
    Principles of Bone Biology, Two-Volume Set
Abstract
Bone and cartilage cells express a wide variety of adhesion. Integrin expression has been studied extensively, but, generally, there is less information on expression of other adhesion molecule family members. Furthermore, there is also relatively little information on the expression and function of adhesion molecules of all classes during skeletal cell development, largely because currently, adequate markers to identify immature bone cells are not present, though the phenotypes of knockout mice are increasingly informative. Adhesion receptors fulfill many functions in the skeleton, and these are frequently linked to a variety of intracellular signaling pathways, leading to a central regulatory role for this class of molecules in bone metabolism. Knowledge of their role in bone resorption and cartilage integrity is extensive, although a function for cell adhesion receptors in bone formation has only been defined recently. Although no unique osteoblast, osteoclast, or chondrocyte adhesion molecule has been identified to date, therapeutic strategies based on selectively inhibiting highly expressed receptors, such as the ?v?3 integrin in osteoclasts, have proved to be successful in regulating excessive bone resorption. Better knowledge of the expression of adhesion molecules in bone and cartilage pathology is required, and elucidation of the role of cell-matrix interactions in the etiology of skeletal disease is likely to, therefore, remain a research challenge for the foreseeable future. © 2008 Elsevier Inc. All rights reserved.
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