The time and costs involved in connecting the IT systems of two companies impact the actual formation of business relationships. A flexible infrastructure for process management is instrumental for rapid and cost-effective B2B integration. One dimension of flexibility that system integrators identify as critical is node-level interaction. In this paper, we discuss the findings of the Nile project on B2B process integration. In particular, we present the methodology defined in Nile for the semi-automatic reconciliation of node-level incompatibilities. (C) 2003 Elsevier B.V. All rights reserved.