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Publication Detail
Cell-geometry-dependent changes in plasma membrane order direct stem cell signalling and fate
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    von Erlach TC, Bertazzo S, Wozniak MA, Horejs CM, Maynard SA, Attwood S, Robinson BK, Autefage H, Kallepitis C, Del Río Hernández A, Chen CS, Goldoni S, Stevens MM
  • Publication date:
    12/02/2018
  • Pagination:
    1, 6
  • Journal:
    Nature Materials
  • Status:
    Accepted
  • Print ISSN:
    1476-1122
Abstract
© 2018 The Author(s) Cell size and shape affect cellular processes such as cell survival, growth and differentiation 1–4 , thus establishing cell geometry as a fundamental regulator of cell physiology. The contributions of the cytoskeleton, specifically actomyosin tension, to these effects have been described, but the exact biophysical mechanisms that translate changes in cell geometry to changes in cell behaviour remain mostly unresolved. Using a variety of innovative materials techniques, we demonstrate that the nanostructure and lipid assembly within the cell plasma membrane are regulated by cell geometry in a ligand-independent manner. These biophysical changes trigger signalling events involving the serine/threonine kinase Akt/protein kinase B (PKB) that direct cell-geometry-dependent mesenchymal stem cell differentiation. Our study defines a central regulatory role by plasma membrane ordered lipid raft microdomains in modulating stem cell differentiation with potential translational applications.
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