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Publication Detail
New insights into cell motility and nanomechanics in confined micro-environments using a microfluidic device
  • Publication Type:
    Conference
  • Authors:
    Wilson KA, LeWalle A, Duke T, Charras GT
  • Publication date:
    01/12/2010
  • Pagination:
    280, 282
  • Published proceedings:
    14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
  • Volume:
    1
  • ISBN-13:
    9781618390622
  • Status:
    Published
Abstract
This paper reports on new insights into cell motility in quasi-3D environments enabled by the use of a microfluidic device for handling cells as well as perturbing front or rear selectively with drugs. Neutrophils are highly motile cells capable of migrating through endothelia, epithelia, and connective tissue. To date, their migration has been studied extensively on planar substrates. However, neutrophils also spend a large proportion of their lifetime migrating through 3D environments. Understanding how this occurs has been hampered by technical hurdles involved in recreating a suitable in vitro model. Microfluidic devices modified from Irimia and coworkers [1] have allowed the real-time interrogation of neutrophil-like HL60 cell migration in response to chemotactic gradients in confined microchannels.
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