Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
New insights into cell motility and nanomechanics in confined micro-environments using a microfluidic device
  • Publication Type:
  • Authors:
    Wilson KA, LeWalle A, Duke T, Charras GT
  • Publication date:
  • Pagination:
    280, 282
  • Published proceedings:
    14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
  • Volume:
  • ISBN-13:
  • Status:
This paper reports on new insights into cell motility in quasi-3D environments enabled by the use of a microfluidic device for handling cells as well as perturbing front or rear selectively with drugs. Neutrophils are highly motile cells capable of migrating through endothelia, epithelia, and connective tissue. To date, their migration has been studied extensively on planar substrates. However, neutrophils also spend a large proportion of their lifetime migrating through 3D environments. Understanding how this occurs has been hampered by technical hurdles involved in recreating a suitable in vitro model. Microfluidic devices modified from Irimia and coworkers [1] have allowed the real-time interrogation of neutrophil-like HL60 cell migration in response to chemotactic gradients in confined microchannels.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
London Centre for Nanotechnology
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by