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Publication Detail
Rap1, canoe and Mbt cooperate with Bazooka to promote zonula adherens assembly in the fly photoreceptor.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Walther RF, Burki M, Pinal N, Rogerson C, Pichaud F
  • Publisher:
    Company of Biologists
  • Publication date:
    05/03/2018
  • Journal:
    Journal of Cell Science
  • Medium:
    Print-Electronic
  • Status:
    Published
  • Print ISSN:
    0021-9533
  • Language:
    eng
  • Addresses:
    MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK.
Abstract
In Drosophila epithelial cells, apical exclusion of Bazooka/Par3 defines the position of the Zonula Adherens (ZA), which demarcates the apical and lateral membrane and allows cells to assemble into sheets. Here, we show that the small GTPase Rap1, its effector AF6/Canoe (Cno) and the Cdc42-effector Pak4/Mushroom bodies tiny (Mbt), converge in regulating epithelial morphogenesis by coupling stabilization of the Adherens Junction (AJ) protein E-Cadherin, and Bazooka retention at the ZA Furthermore, our results show that the localization of Rap1, Cno and Mbt at the ZA is interdependent, indicating their functions during ZA morphogenesis are interlinked. In this context, we find the Rap1-GEF Dizzy is enriched at the ZA and our results suggest it promotes Rap1 activity during ZA morphogenesis. Altogether, we propose the Dizzy, Rap1/Cno pathway and Mbt converge in regulating the interface between Bazooka and AJ material to promote ZA morphogenesis.
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