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Publication Detail
Facile meltPEGylation of flame-made luminescent Tb3+-doped yttrium oxide particles: hemocompatibility, cellular uptake and comparison to silica
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Keevend K, Panzarasa G, Starsich FHL, Zeltner M, Spyrogianni A, Tsolaki E, Fortunato G, Pratsinis SE, Bertazzo S, Herrmann IK
  • Publication date:
    19/02/2018
  • Pagination:
    2914, 2917
  • Journal:
    Chemical Communications
  • Volume:
    54
  • Issue:
    23
  • Status:
    Published
  • Print ISSN:
    1359-7345
Abstract
© 2018 The Royal Society of Chemistry. Flame aerosol technology is a versatile method for scalable synthesis of nanoparticles. Since particles are produced and collected in a dry state, dispersibility and further functionalization could pose hurdles to their biomedical use. We report on a one-pot, scalable and robust procedure for the PEGylation of flame-made yttria and silica nanoparticles. We demonstrate improved colloidal stability, attenuated activation of blood coagulation and decreased uptake into phagocytic cells, all of which pave the way for facilitated biomedical use of flame-made oxide nanoparticles.
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