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Publication Detail
Development of in-vivo fluorescence imaging with the Matrix-Free method
  • Publication Type:
    Conference
  • Authors:
    Zacharopoulos A, Garofalakis A, Ripoll J, Arridge S
  • Publication date:
    01/01/2010
  • Published proceedings:
    Journal of Physics: Conference Series
  • Volume:
    255
  • Issue:
    1
  • Status:
    Published
  • Print ISSN:
    1742-6588
Abstract
Non-contact Fluorescence Molecular Tomography is an emerging technique for imaging of fluorescent probes or proteins in live animals. One of the main characteristics of the non-contact acquisition systems in comparison to the usual fibre-based systems is the much denser boundary data sets that are created. When model-based reconstruction methods are used that rely on the inversion of a derivative operator, the large number of measurements poses a challenge since the explicit formulation and storage of the Jacobian matrix could be in general not feasible. In this paper we test a matrix-free method that addresses the problems of large data sets and reduces the computational cost and memory requirements for the reconstruction. More specifically we challenged the Matrix-Free method with in-vivo measurements from mice where fluorescence tubes of different but controlled concentrations are inserted, to assess the quantification performance of the method. We extended the test with simulations, using realistic geometries extracted from a mouse-atlas and including prior known information about the optical properties of tissue into the forward model. © 2010 IOP Publishing Ltd.
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