UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at http://www.ucl.ac.uk/finance/research/post_award/post_award_contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Mitochondrial bioenergetics assessed by functional fluorescence dyes
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Corona JC, Duchen MR
  • Publication date:
    01/01/2014
  • Pagination:
    161, 176
  • Journal:
    Neuromethods
  • Volume:
    90
  • Status:
    Published
  • Print ISSN:
    0893-2336
Abstract
© Springer Science+Business Media New York 2015. Mitochondria play key roles in physiology and in disease. Understanding the mechanisms that defi ne mitochondrial function, the regulation of energy balance in the cell, and the ways in which mitochondrial dysfunction impacts on cell physiology represents a key challenge in modern cellular pathophysiology. This requires a study of mitochondrial function in relation to the physiology of the cell, and so has driven approaches to measure and characterize key aspects of mitochondrial function within living cells. Central to this advance has been the use of fluorescent indicators that report mitochondrial membrane potential, mitochondrial redox state, rates of free radical generation, ATP, and so on. In this chapter we provide a critical appraisal and guide to the measurement of mitochondrial bioenergetics within living cells and discuss both the strengths and potential pitfalls of the most useful probes for mitochondrial membrane potential using confocal microscopy and flow cytometry.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Cell & Developmental Biology
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by