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Publication Detail
Neuronal mitochondrial transport and dysfunction
  • Publication Type:
    Chapter
  • Authors:
    Atkin TA, MacAskill AF, Kittler JT
  • Publication date:
    01/01/2012
  • Pagination:
    157, 173
  • ISBN-13:
    9780857297006
  • Status:
    Published
  • Book title:
    Mitochondrial Dysfunction in Neurodegenerative Disorders
Abstract
Neuronal function is dependent on energy provision by mitochondria. It has recently emerged that the precise localization of mitochondria at regions with high energy demands such as the active synapse is required to facilitate continued synaptic transmission and plasticity. Therefore, understanding how mitochondrial distribution is controlled in neurons is crucial for understanding both healthy neuronal function and potential disease mechanisms. Here, we discuss the machinery responsible for active transport of mitochondria throughout the neuron and the mechanisms in place which allow the activity-dependent regulation of trafficking to and from active synapses. We then discuss recent evidence implicating disrupted mitochondrial transport in neurodegenerative disorders including Alzheimer’s, Parkinson’s, Huntington’s, and Charcot–Marie–Tooth Disease, and Amyloid Lateral Sclerosis.
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